Longitudinal Changes of Macular Curvature in Patients with Retinitis Pigmentosa
| Autor: | Shiori Komori, Yoshito Koyanagi, Monika Meinert, Taro Kominami, Yasuki Ito, Shinji Ueno, Sten Andréasson, Akira Sayo, Hiroko Terasaki |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty genetic structures macular curvature Biomedical Engineering Curvature spectral domain optical coherence Article Macular Edema 03 medical and health sciences 0302 clinical medicine Optical coherence tomography Ophthalmology retinitis pigmentosa Retinitis pigmentosa medicine Humans In patient Macula Lutea ellipsoid zone Macular edema retinal photoreceptor layer Mean curvature medicine.diagnostic_test business.industry Axial length medicine.disease eye diseases 030104 developmental biology Retinal Prosthesis 030221 ophthalmology & optometry sense organs Bruch Membrane business Tomography Optical Coherence |
| Zdroj: | Translational Vision Science & Technology |
| ISSN: | 2164-2591 |
| Popis: | Purpose: To investigate the longitudinal changes of the macular curvature in eyes with retinitis pigmentosa (RP) and to determine the factors associated with the changes. Methods: We reviewed the medical charts of 107 RP patients, for whom the axial length of their right eyes ranged from 21.5 to 26.0 mm and who had had been followed by spectral-domain optical coherence tomography (OCT). The OCT images at the initial and the most recent examinations were compared. The mean curvature of Bruch’s membrane within 6 mm of the central macula obtained from the OCT images was evalu-ated as the mean macular curvature index (MMCI). Changes in the MMCI and their relationships with other clinical factors, including the ellipsoid zone (EZ) width, were assessed. Results: The MMCI decreased significantly in the vertical OCT images, from –15.47 × 10−5 μm−1 to –16.36 × 10−5 μm−1 (P = 0.008) during the mean observation period of 3.4 ± 1.4 years (mean ± SD). This indicated that the macular shape became more concave. The change to a steeper shape was more prominent in eyes with less photoreceptor degeneration and for which the EZ width was preserved at >2000 μm. In three eyes, the MMCI increased markedly by >5 × 10−5 μm−1, and this was accompanied by absorption of the macular edema. Conclusions: The macular curvature in RP eyes becomes more concave in eyes with preserved EZ width. Translational Relevance: Longitudinal changes of the macular curvature in RP should be considered in future therapies, such as the implantation of the retinal prosthesis. (Less) |
| Databáze: | OpenAIRE |
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