Premedication with reformulated simethicone and sodium bicarbonate improves mucosal visibility during upper gastrointestinal endoscopy: a double-blind, multicenter, randomized controlled trial
| Autor: | Ning Dai, Mingqing Zhang, Yanyong Deng, Jianmin Si, Xin Sun, Xueqin Chen, Guoliang Ye, Zhiming Huang, Jie Pan, Lan Wang, Shujie Chen |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Premedication Simethicone Mixed solution Gastroenterology Esophagogastroduodenoscopy Endoscopy Gastrointestinal law.invention Double blind 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Randomized controlled trial Double-Blind Method law Internal medicine Medicine Humans lcsh:RC799-869 Sodium bicarbonate medicine.diagnostic_test Reformulated simethicone emulsion business.industry General Medicine White flocculate precipitate Upper gastrointestinal endoscopy Sodium Bicarbonate chemistry 030220 oncology & carcinogenesis lcsh:Diseases of the digestive system. Gastroenterology 030211 gastroenterology & hepatology business medicine.drug Research Article |
| Zdroj: | BMC Gastroenterology BMC Gastroenterology, Vol 21, Iss 1, Pp 1-9 (2021) |
| ISSN: | 1471-230X |
| Popis: | Background The reformulated simethicone emulsion from Berlin Chemical AG might develop white flocculate precipitate covering the gastric mucosa when used before esophagogastroduodenoscopy (EGD). We aim to investigate whether combining the reformulated simethicone emulsion with 5% sodium bicarbonate solution could prevent the development of white precipitate and improve visibility during EGD. Methods Our clinical study involved 523 patients. They were randomly assigned to two groups. In Group A, patients received a warm solution containing 30 ml 5% sodium bicarbonate solution and 15 ml reformulated simethicone emulsion. In Group B, patients received 45 ml 40 °C lukewarm water. Visibility scores were recorded and analyzed. Flushes, volume of flush water, overall time taken for EGD and complications during or after the procedure were also recorded. Results We found that no white precipitate was observed during EGD in Group A. Moreover, visibility scores in Group A were significantly lower (P P P P P Conclusions Premedication with a mixed solution of 15 ml reformulated simethicone emulsion and 30 ml 5% sodium bicarbonate solution can prevent the development of white precipitate, substantially enhancing mucosal visibility safely. Trial registration: The registered name of the trial is “Efficacy of using premedication with reformulated simethicone emulsion during upper gastrointestinal endoscopy examination”. Its Current Controlled Trials number is ChiCTR1900021689. Its date of registration is 11 September 2019. Retrospectively registered, http://www.medresman.org.cn/uc/sindex.aspx. |
| Databáze: | OpenAIRE |
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