Aerosolization properties, surface composition and physical state of spray-dried protein powders
| Autor: | Cynthia Bosquillon, François Ahimou, Véronique Préat, Christine Culot, Rita Vanbever, Paul Rouxhet, Denis Simon |
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| Rok vydání: | 2004 |
| Předmět: |
Protein Denaturation
1 2-Dipalmitoylphosphatidylcholine Surface Properties Chemistry Pharmaceutical Pharmaceutical Science Lactose law.invention Excipients chemistry.chemical_compound Drug Stability law Albumins Phase (matter) Administration Inhalation Humans Particle Size Crystallization Aerosols Drug Carriers Chromatography Spectrometry X-Ray Emission Water chemistry Chemical engineering Dipalmitoylphosphatidylcholine Spray drying Wettability Particle Wetting Particle size Powders Porosity |
| Zdroj: | Journal of Controlled Release. 99:357-367 |
| ISSN: | 0168-3659 |
| DOI: | 10.1016/j.jconrel.2004.07.022 |
| Popis: | Powder aerosols made of albumin, dipalmitoylphosphatidylcholine (DPPC) and a protein stabilizer (lactose, trehalose or mannitol) were prepared by spray-drying and analyzed for aerodynamic behavior, surface composition and physical state. The powders exited a Spinhaler inhaler as particle aggregates, the size of which depending on composition, spray-drying parameters and airflow rate. However, due to low bulk powder tap density ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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