Polymeric nanocapsules as a technological alternative to reduce the toxicity caused by meloxicam in mice
| Autor: | Angélica S. Reis, Rodrigo de Almeida Vaucher, Benonio T. Villalba, Mikaela P. Pinz, Ane G. Vogt, Cristiane Luchese, Francine R. Ianiski, Ethel A. Wilhelm, Mauro P. Soares |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Bilirubin Thiazines Polysorbates Pharmacology Meloxicam Toxicology 030226 pharmacology & pharmacy Nanocapsules Lipid peroxidation Lactones Mice Structure-Activity Relationship 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Animals Caproates Dose-Response Relationship Drug Stomach Body Weight Albumin Organ Size General Medicine Thiazoles 030104 developmental biology medicine.anatomical_structure Liver chemistry Gastric Mucosa Toxicity Alkaline phosphatase Lipid Peroxidation medicine.drug |
| Zdroj: | Regulatory Toxicology and Pharmacology. 81:316-321 |
| ISSN: | 0273-2300 |
| DOI: | 10.1016/j.yrtph.2016.09.023 |
| Popis: | This study determined whether meloxicam in nanocapsules modifies stomach and liver damage caused by free meloxicam in mice. Male Swiss mice were treated with blank nanocapsules or meloxicam in nanocapsules or free meloxicam (10 mg/kg, intragastrically, daily for five days). On the seventh day, blood was collected to determine biochemical markers (glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, total bilirubin, unconjugated bilirubin, albumin and alkaline phosphatase). Stomachs and livers were removed for histological analysis. There was no significant difference in the biochemical markers in the plasma of mice. Meloxicam in nanocapsules did not have an ulcerogenic potential in the stomach or cause lipid peroxidation in the stomach and liver. Free meloxicam increased the ulcerogenic potential in the stomach and lipid peroxidation in the stomach and liver. Meloxicam in nanocapsules caused less histological changes than free meloxicam. In conclusion, polymeric nanocapsules can represent a technological alternative to reduce the toxicity caused by meloxicam. |
| Databáze: | OpenAIRE |
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