Endothelial Dysfunction in Systemic Lupus Erythematosus: Evaluation with 13N-Ammonia PET
| Autor: | Aloha Meave, E. Romero, Rodrigo Calleja, Carlos Posadas-Romero, Juan Manuel Alducín Ochoa, Erick Alexanderson, Juan Gabriel Juárez-Rojas, John O. Prior, Rodrigo Jácome |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
medicine.medical_specialty Vasodilation Coronary Artery Disease Asymptomatic Ammonia immune system diseases Coronary Circulation Internal medicine Image Interpretation Computer-Assisted Active disease Healthy control Pressure Humans Lupus Erythematosus Systemic Medicine Radiology Nuclear Medicine and imaging Endothelial dysfunction skin and connective tissue diseases Nitrogen Radioisotopes (13N)Ammonia business.industry Hemodynamics Cold pressor test Blood flow medicine.disease Cold Temperature Endocrinology Positron-Emission Tomography Cardiology Female Endothelium Vascular Radiopharmaceuticals medicine.symptom business Stress Psychological |
| Zdroj: | Journal of Nuclear Medicine. 51:1927-1931 |
| ISSN: | 2159-662X 0161-5505 |
| Popis: | Systemic lupus erythematosus (SLE) affects multiple organs and systems, severely involving the cardiovascular system. The aim of this study was to evaluate the presence of endothelial dysfunction with 13N-ammonia PET in asymptomatic SLE patients. Methods: We enrolled 16 women with SLE and 16 healthy women. Myocardial blood flow (MBF) was quantified in a 64-slice PET/CT scanner at rest, during a cold pressor test (CPT), and during stress. Endothelium-dependent vasodilation index, %ΔMBF, and myocardial flow reserve (MFR) were calculated. Results: There were 16 women in the SLE group (mean age ± SD, 31.4 ± 8.3 y) and 16 women in the healthy control group (31.5 ± 11.1 y). Mean endothelium-dependent vasodilatation index and %ΔMBF were significantly lower in SLE patients (1.18 ± 0.55 vs. 1.63 ± 0.65, P = 0.04, and 18 ± 55 vs. 63 ± 65, P = 0.04, respectively). MFR was also lower in the SLE group (2.41 ± 0.59 vs. 2.73 ± 0.77, P = 0.20). Conclusion: SLE patients who are free of active disease present abnormal coronary flow and endothelial dysfunction. It is necessary to develop and intensify treatment strategies directed to CAD in SLE patients. |
| Databáze: | OpenAIRE |
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