Glycyrrhizin Suppresses the Growth of Human NSCLC Cell Line HCC827 by Downregulating HMGB1 Level

Autor: Jindong Wang, Dawei Yuan, Jie Mou, Tao Yu, Xiaobin Qin, Xiaojin Wu, Yuan‐yuan Chen, Guangxia Chen, Yanyan Mi, Ankang Hu, Dong-Sheng Pei, Weitao Wang, Xiangqun Liu, Jinpeng Cui, Yunxiang E
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Lung Neoplasms
Article Subject
Regulator
lcsh:Medicine
Down-Regulation
Mice
Nude
HMGB1
Inhibitory postsynaptic potential
General Biochemistry
Genetics and Molecular Biology
Mice
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Cell Movement
Carcinoma
Non-Small-Cell Lung
Cell Line
Tumor
medicine
Carcinoma
Animals
Humans
Neoplasm Invasiveness
HMGB1 Protein
Glycyrrhizin
Lung cancer
Cell Proliferation
Janus Kinases
General Immunology and Microbiology
biology
lcsh:R
General Medicine
respiratory system
Glycyrrhizic Acid
medicine.disease
In vitro
respiratory tract diseases
STAT Transcription Factors
030104 developmental biology
chemistry
Cell culture
030220 oncology & carcinogenesis
biology.protein
Cancer research
Research Article
Signal Transduction
Zdroj: BioMed Research International
BioMed Research International, Vol 2018 (2018)
ISSN: 2314-6133
DOI: 10.1155/2018/6916797
Popis: Lung cancer has very high mortality and glycyrrhizin was found to significantly inhibit the growth of lung cancer cells in vitro and tissues in mice. However, the detailed inhibitory role of glycyrrhizin in the growth of lung cancer is still unclear. In this study, we first found that glycyrrhizin inhibited the growth of lung tumor in PDX mice. And high level of HMGB1 promoted the migration and invasion of lung cancer cells, which was suppressed by glycyrrhizin. Moreover, glycyrrhizin reduced the activity of JAK/STAT signaling pathway, which is the upstream regulator of HMGB1. Therefore, this study revealed a potential mechanism by which glycyrrhizin can inhibit the progression of lung cancer.
Databáze: OpenAIRE
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