TIME-DEPENDENCY OF NEUROHYPOPHYSEAL PEPTIDE ATTENUATION OF PUROMYCIN AMNESIA IN MICE
| Autor: | Louis B. Flexner, Paula L. Hoffman, Josefa B. Flexner, Roderich Walter |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Vasopressin
medicine.medical_specialty Time Factors Arginine Vasopressins Hypothalamus Amnesia Peptide Tripeptide Biochemistry Arousal Mice chemistry.chemical_compound Memory Internal medicine medicine Animals Humans Neurophysins chemistry.chemical_classification Arginine Vasopressin Endocrinology chemistry Puromycin medicine.symptom Oligopeptides Hormone |
| Zdroj: | International Journal of Peptide and Protein Research. 16:482-486 |
| ISSN: | 0367-8377 |
| DOI: | 10.1111/j.1399-3011.1980.tb02973.x |
| Popis: | [Ile3, Arg8]. vasopressin (arginine-vasotocin), as well as the C-terminal tripeptides of the neurohypophyseal hormones arginine and lysine vasopressin, Pro-Arg-Gly-NH2 and Pro-Lys-Gly-NH2, were protective against puromycin-induced amnesia in mice when administered 24h before training. The N-protected tripeptide derivative, Z-Pro-Lys-Gly-NH2, was effective when given 5 days before training. The effectiveness of all peptides to attenuate puromycin-induced amnesia decreased as the interval between training and peptide treatment increased, indicating that the peptides influence memory processes, rather than general arousal. Z-Pro-Lys-Gly-NH2 was active at 24h after training, when the other peptides were no longer effective. Although it seems clear that neurohypophyseal hormones per se can attenuate puromycin-induced amnesia, these results are in line with the possibility that some portion of hormone action may be mediated via formation of longer-lived hormone fragments in the CNS. |
| Databáze: | OpenAIRE |
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