Suppression of uterine activity and abortion by inhibition of prostaglandin synthesis
| Autor: | H.L. Kaihola, Arpad I. Csapo, M.O. Pulkkinen, Milan R. Henzl, A. Kivikoski |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Adult
medicine.medical_specialty Time Factors Hypertonic Solutions Uterus Prostaglandin Naphthalenes Sodium Chloride Abortion Oxytocin Placebo Biochemistry Placebos chemistry.chemical_compound Endocrinology Pregnancy Internal medicine Pressure medicine Humans Endocrine system Progesterone Clinical Trials as Topic Estradiol business.industry Abortion Induced Hypertonic saline medicine.anatomical_structure chemistry Depression Chemical Prostaglandins Female Propionates business Hormone medicine.drug |
| Zdroj: | Prostaglandins. 7:39-47 |
| ISSN: | 0090-6980 |
| Popis: | The premise has been examined that the evolution of uterine activity, provoked by progesterone(P)-deficiency and consequent prostaglandin(PG)-dominance, can be suppressed in patients by inhibiting PG-synthesis. In 20 midtrimester pregnant women P-deficiency, evolution of intrauterine pressure (IUP), oxytocin response (OR) and abortion had been induced by the hypertonic saline technique and the changes in P and E2 levels and in IUP and OR measured sequentially. According to a "double blind" protocol, 10 volunteers received placebo, while another 10 were treated during 14 hours with 1050 mg naproxen, an inhibitor of PG-synthesis. Significant decrease in plasma progesterone (P 0.001) and estradiol 17Beta (P 0.02) preceding clinical progress in abortion demonstrated that hypertonic saline suppressed the endocrine function of the fetoplacental unit in both groups of patients. In spite of a 40% reduction in the P-levels of the experimental group (at a time when the controls aborted) the evolution of IUP, OR and abortion in the naproxen treated had been delayed by about 30 hours. This significant delay in all the measured parameters (P 0.001) is evidence that inhibition of PG-synthesis prevents the endogenous activation of the uterus in patients, as it does in animal "models". |
| Databáze: | OpenAIRE |
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