Hedgehog signaling mechanism and role in cancer
| Autor: | Jin Jiang |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
0301 basic medicine
Cancer Research Repressor Biology Zinc Finger Protein GLI1 Article Receptors G-Protein-Coupled 03 medical and health sciences 0302 clinical medicine Neoplasms Animals Humans Hedgehog Proteins Hedgehog Transcription factor Tissue homeostasis G protein-coupled receptor Hedgehog signaling pathway Cell biology 030104 developmental biology 030220 oncology & carcinogenesis Drosophila Signal transduction Smoothened Signal Transduction Transcription Factors |
| Zdroj: | Semin Cancer Biol |
| ISSN: | 1044-579X |
| Popis: | Cell-cell communication through evolutionarily conserved signaling pathways governs embryonic development and adult tissue homeostasis. Deregulation of these signaling pathways has been implicated in a wide range of human diseases including cancer. One such pathway is the Hedgehog (Hh) pathway, which was originally discovered in Drosophila and later found to play a fundamental role in human development and diseases. Abnormal Hh pathway activation is a major driver of basal cell carcinomas (BCC) and medulloblastoma. Hh exerts it biological influence through a largely conserved signal transduction pathway from the activation of the GPCR family transmembrane protein Smoothened (Smo) to the conversion of latent Zn-finger transcription factors Gli/Ci proteins from their repressor (GliR/CiR) to activator (GliA/CiA) forms. Studies from model organisms and human patients have provided deep insight into the Hh signal transduction mechanisms, revealed roles of Hh signaling in a wide range of human cancers, and suggested multiple strategies for targeting this pathway in cancer treatment. |
| Databáze: | OpenAIRE |
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