Effect of the prolactin-release inhibitor quinagolide on lactating dairy cows
| Autor: | Marion Boutinaud, G.F. Wagner, Vanessa Lollivier, Pierre Lacasse, Rupert M. Bruckmaier, Yves R. Boisclair |
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| Přispěvatelé: | Production du lait (PL), Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), INRA, Agriculture and Agri-Food Canada |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Mammary gland
stanniocalcin milking frequency bovine growth-hormone fluids and secretions Lactation MESH: Aminoquinolines Bovine somatotropin MESH: Animals Udder 0303 health sciences food and beverages 04 agricultural and veterinary sciences secretion MESH: Cattle medicine.anatomical_structure Milk milk synthesis [SDV.SA.SPA]Life Sciences [q-bio]/Agricultural sciences/Animal production studies Aminoquinolines Female hormones hormone substitutes and hormone antagonists medicine.medical_specialty endocrine system prolactin MESH: Lactation MESH: Prolactin lactation Biology leptin Milking 03 medical and health sciences serum prolactin Internal medicine oxytocin Genetics medicine Animals Dairy cattle 030304 developmental biology Quinagolide 0402 animal and dairy science exogenous yield 040201 dairy & animal science gene-expression Prolactin MESH: Milk Endocrinology Animal Science and Zoology Cattle mammary-gland MESH: Female Food Science |
| Zdroj: | Journal of Dairy Science Journal of Dairy Science, American Dairy Science Association, 2011, 94 (3), pp.1302-9. ⟨10.3168/jds.2010-3649⟩ |
| ISSN: | 0022-0302 |
| DOI: | 10.3168/jds.2010-3649⟩ |
| Popis: | In most mammals, prolactin (PRL) is essential for maintaining lactation, and yet the short-term suppression of PRL during established lactation by bromocriptine has produced inconsistent effects on milk yield in cows and goats. To assess the effect of the long-term inhibition of PRL release in lactating dairy cows, 5 Holstein cows in early lactation received daily intramuscular injections of 1mg of the PRL-release inhibitor quinagolide for 9 wk. Four control cows received the vehicle (water) only. During the last week of the treatments, one udder half was milked once a day (1×) and the other twice a day (2×). Blood samples were harvested at milking in wk -1, 1, 4, and 8. The daily injections of quinagolide reduced milking-induced PRL release but not the basal PRL concentration. Quinagolide induced a faster decline in milk production, which was about 5.3 kg/d lower in the quinagolide-treated cows during the last 4 wk of treatment. During wk 9, the inhibition of milk production by quinagolide was maintained in the udder half that was milked 2× but not in the half milked 1×. Milk production was significantly correlated with the quantity of PRL released at milking. Quinagolide did not affect the release of oxytocin at milking. Serum concentration of insulin-like growth factor-1 was not affected by treatment or correlated with milk production. Serum concentrations of leptin and the calciotropic hormone stanniocalcin were not affected by the treatment. In conclusion, the chronic administration of the PRL-release inhibitor quinagolide decreases milk production in dairy cows. The effect is likely the result of the reduced release of milking-induced PRL and is modulated at the level of the gland by milking frequency. |
| Databáze: | OpenAIRE |
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