Placental abruption possibly due to parvovirus B19 infection
| Autor: | Kouki Samejima, Yasushi Takai, Hiroyuki Seki, Ayaka Kawabe, Jun-ichi Tamaru |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
viruses
Apoptosis 03 medical and health sciences 0302 clinical medicine Glycolipid Antigen Pregnancy hemic and lymphatic diseases Neonatal asphyxia medicine 030212 general & internal medicine Receptor 030219 obstetrics & reproductive medicine Multidisciplinary biology Globoside Placental abruption Case Study Parvovirus business.industry Trophoblast virus diseases biology.organism_classification medicine.disease Virology medicine.anatomical_structure Immunology embryonic structures business Human parvovirus B19 |
| Zdroj: | SpringerPlus |
| ISSN: | 2193-1801 |
| Popis: | Background There is concern about the development of anemia-associated fetal hydrops associated with maternal parvovirus B19 infection. Parvovirus B19 infection occurs via the globoside (P antigen) receptor, the main glycolipid of erythroid cells, which induces apoptosis. Similar findings have been reported for the P antigen of globoside-containing placental trophoblast cells. Case description A 32-year-old woman was infected with human parvovirus B19 at week 32 of pregnancy, and had severe anemia at week 34. At week 37, an emergency cesarean section was performed because of sudden abdominal pain and fetal bradycardia; placental abruption was found. A live male infant was delivered with no sign of fetal hydrops or fetal infection. Placental tissue was positive for parvovirus B19 according to polymerase chain reaction. Immunohistochemical analysis using caspase-related M30 CytoDEATH monoclonal antibody revealed M30 staining of the placental villous trophoblasts. Discussion and evaluation Placental trophoblasts and erythroid precursor cells have been reported to express globoside (P antigen), which is necessary for parvovirus B19 infectivity, and to show apoptotic activity as a result of infection. Placentas from three other pregnancies with documented abruption showed no M30 staining. Conclusion The present case strongly suggests an association between placental abruption and apoptosis resulting from parvovirus B19 infection. |
| Databáze: | OpenAIRE |
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