Low leucocyte myeloperoxidase activity in patients with multiple sclerosis
| Autor: | A.V. Arutjunyan, G Ramsaransing, de Jacques Keyser, Aw Teelken, VM Prokopenko |
|---|---|
| Přispěvatelé: | Gerontology |
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
INVOLVEMENT
Adult Male medicine.medical_specialty Multiple Sclerosis Encephalomyelitis Short Report Peroxidase/genetics/*pharmacology TAURINE CHLORAMINE SUSCEPTIBILITY MYELIN BASIC-PROTEIN Severity of Illness Index Pathogenesis Central nervous system disease Multiple Sclerosis/genetics/*physiopathology Internal medicine medicine Leukocytes Humans In patient Peroxidase biology Multiple sclerosis Case-control study PEPTIDES ASSOCIATION Leukocytes/enzymology Middle Aged medicine.disease POLYMORPHISM Myelin basic protein Psychiatry and Mental health Endocrinology Myeloperoxidase Case-Control Studies biology.protein Disease Progression ENCEPHALOMYELITIS Surgery T-CELL REACTIVITY Female Neurology (clinical) SCREEN Human |
| Zdroj: | JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 74(7), 953-955. BMJ PUBLISHING GROUP |
| ISSN: | 0022-3050 |
| Popis: | The gene for myeloperoxidase (MPO) has been implicated in multiple sclerosis (MS). By measuring H(2)O(2) dependent oxidation of 3,3'5,5'-tetramethylbenzidine with spectrophotometry the authors investigated MPO activity in peripheral blood leucocytes from 42 patients with MS (12 with secondary progressive MS, 17 with primary progressive MS, and 13 with relapsing remitting benign MS) and 32 healthy controls. Leucocyte MPO activity was significantly lower in patients with benign MS (mean (SEM) 0.086 (0.029) U/mg protein; p0.01), secondary progressive MS (0.038 (0.009) U/mg protein; p0.001), and primary progressive MS (0.057 (0.016) U/mg protein; p0.001) compared with healthy controls (0.322 (0.053) U/mg protein). These data suggest that low MPO, which may be genetically determined, plays a part in MS pathogenesis. |
| Databáze: | OpenAIRE |
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