Marrow transplantation in treatment of children with aplastic anaemia or acute leukaemia
| Autor: | Buckner Cd, John Hersman, Thomas Ed, Rainer Storb, J R Hartmann, R L Chard, Reginald A. Clift, F L Jonson |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Graft Rejection
Male medicine.medical_specialty Adolescent Cyclophosphamide Bone marrow transplantation Remission Spontaneous Bone Marrow Cells Spontaneous remission Disease Gastroenterology Graft vs Host Reaction Refractory Internal medicine Humans Transplantation Homologous Medicine Child Bone Marrow Transplantation Graft rejection Marrow transplantation business.industry Anemia Aplastic Total body irradiation Leukemia Lymphoid Surgery Leukemia Myeloid Acute Child Preschool Pediatrics Perinatology and Child Health Female business Research Article medicine.drug |
| Zdroj: | Archives of Disease in Childhood. 51:403-410 |
| ISSN: | 1468-2044 0003-9888 |
| DOI: | 10.1136/adc.51.6.403 |
| Popis: | Seventy-six patients, aged 2 to 17 years, were treated with bone marrow transplantation for severe aplastic anaemia or acute leukaemia refractory to conventional therapy. 16 of the 22 patients (73%) who received marrow transplantations for aplastic anaemia are surviving, 12 of these for over one year. In acute leukaemia, using preparation with cyclophosphamide and total body irradiation, 8 of 33 patients (24%) receiving allogeneic and 5 of 8 (63%) receiving syngeneic transplantations are continuing in remission from 3 months to beyond 2 years. The longest continuing remission off therapy is now over 4 1/2 years after preparation with total body irradiation. The major causes of failure remain graft-versus-host disease, infection, graft rejection (aplastic anaemia), and leukaemic relapse. |
| Databáze: | OpenAIRE |
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