Evaluation of a type 2 modified live porcine reproductive and respiratory syndrome vaccine against heterologous challenge of a lineage 3 highly virulent isolate in pigs
| Autor: | Chih-Jung Kuo, Han-Ping Chung, Wei-Cheng Lee, Jiunn-Wang Liao, Maw-Sheng Chien, Min-Yuan Chia, Fu-Hsiang Hou |
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| Rok vydání: | 2020 |
| Předmět: |
Veterinary Medicine
040301 veterinary sciences animal diseases viruses Immunology lcsh:Medicine Virulence Heterologous Viremia Biology Porcine reproductive and respiratory syndrome General Biochemistry Genetics and Molecular Biology 0403 veterinary science 03 medical and health sciences Virology Genotype medicine Respiratory system 030304 developmental biology 0303 health sciences Respiratory distress General Neuroscience lcsh:R 04 agricultural and veterinary sciences General Medicine biochemical phenomena metabolism and nutrition medicine.disease Modified live virus Vaccination Titer Infectious Diseases General Agricultural and Biological Sciences Vaccine Cross-protection |
| Zdroj: | PeerJ, Vol 8, p e8840 (2020) PeerJ |
| ISSN: | 2167-8359 |
| Popis: | Porcine reproductive and respiratory syndrome (PRRS) is one of the most common diseases in the global swine industry. PRRSV is characterized by rapid mutation rates and extensive genetic divergences. It is divided into two genotypes, which are composed of several distinct sub-lineages. The purpose of the present study was to evaluate the cross-protective efficacy of Fostera PRRS MLV, an attenuated lineage 8 strain, against the heterologous challenge of a lineage 3 isolate. Eighteen pigs were randomly divided into mock, MLV and unvaccinated (UnV) groups. The pigs in the MLV group were administered Fostera PRRS vaccine at 3 weeks of age and both the MLV and UnV groups were inoculated with a virulent PRRSV isolate at 7 weeks. Clinically, the MLV group showed a shorter duration and a lower magnitude of respiratory distress than the UnV group. The average days of fever in the MLV group was 3.0 ± 0.5, which was significantly lower than the 6.2 ± 0.5 days of the UnV group (P 1−101.5 genomic copies) than those of the UnV pigs from 4 to 14 DPC. In conclusion, vaccination with Fostera PRRS MLV confers partial cross-protection against heterologous challenge of a virulent lineage 3 PRRSV isolate. |
| Databáze: | OpenAIRE |
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