Penetration enhancers in ocular drug delivery
| Autor: | Fraser Steele, Peter W. J. Morrison, Roman V. Moiseev, Vitaliy V. Khutoryanskiy |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
genetic structures
lcsh:RS1-441 Pharmaceutical Science 02 engineering and technology Review Pharmacology 030226 pharmacology & pharmacy ocular drug delivery lcsh:Pharmacy and materia medica 03 medical and health sciences 0302 clinical medicine Drug permeability cornea Medicine Pharmaceutical sciences Enhancer ocular conditions business.industry Penetration (firestop) 021001 nanoscience & nanotechnology eye diseases ophthalmology penetration enhancers Drug delivery sense organs 0210 nano-technology business |
| Zdroj: | Pharmaceutics Pharmaceutics, Vol 11, Iss 7, p 321 (2019) |
| ISSN: | 1999-4923 |
| Popis: | There are more than 100 recognized disorders of the eye. This makes the development of advanced ocular formulations an important topic in pharmaceutical science. One of the ways to improve drug delivery to the eye is the use of penetration enhancers. These are defined as compounds capable of enhancing drug permeability across ocular membranes. This review paper provides an overview of anatomical and physiological features of the eye and discusses some common ophthalmological conditions and permeability of ocular membranes. The review also presents the analysis of literature on the use of penetration-enhancing compounds (cyclodextrins, chelating agents, crown ethers, bile acids and bile salts, cell-penetrating peptides, and other amphiphilic compounds) in ocular drug delivery, describing their properties and modes of action. |
| Databáze: | OpenAIRE |
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