In vitro and in silico analysis of galanthine from Zephyranthes carinata as an inhibitor of acetylcholinesterase

Autor:	Karina Sierra, Jean Paulo de Andrade, Luciana R. Tallini, Edison H. Osorio, Osvaldo Yañéz, Manuel Isaías Osorio, Nora H. Oleas, Olimpo García-Beltrán, Warley de S. Borges, Jaume Bastida, Edison Osorio, Natalie Cortes
Rok vydání:	2022
Předmět:	Molecular Docking Simulation Pharmacology Alkaloids Butyrylcholinesterase Amaryllidaceae Acetylcholinesterase Cholinesterase Inhibitors General Medicine
Zdroj:	Biomedicine & Pharmacotherapy. 150:113016
ISSN:	0753-3322
DOI:	10.1016/j.biopha.2022.113016
Popis:	Zephyranthes carinata Herb., a specie of the Amaryllidoideae subfamily, has been reported to have inhibitory activity against acetylcholinesterase. However, scientific evidence related to their bioactive alkaloids has been lacking. Thus, this study describes the isolation of the alkaloids of this plant, and their inhibition of the enzymes acetylcholinesterase (eeAChE) and butyrylcholinesterase (eqBuChE), being galanthine the main component. Additionally, haemanthamine, hamayne, lycoramine, lycorine, tazettine, trisphaeridine and vittatine/crinine were also isolated. The results showed that galanthine has significant activity at low micromolar concentrations for eeAChE (IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2585257166644afebf42c8776ef5bd9 https://doi.org/10.1016/j.biopha.2022.113016 Zobrazit plný text záznamu Full Text from ScienceDirect