CXCL12 and Its Isoforms: Different Roles in Pancreatic Cancer?
| Autor: | Matteo Giulietti, Giovanni Principato, Berina Sabanovic, Alessandra Righetti, Francesco Piva, Giulia Occhipinti |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Tumor microenvironment Stromal cell Angiogenesis business.industry Review Article lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease lcsh:RC254-282 biological factors Metastasis 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Pancreatic cancer embryonic structures Cancer cell Cancer research medicine Epithelial–mesenchymal transition Pancreas business |
| Zdroj: | Journal of Oncology Journal of Oncology, Vol 2019 (2019) |
| ISSN: | 1687-8469 1687-8450 |
| DOI: | 10.1155/2019/9681698 |
| Popis: | CXCL12 is a chemokine that acts through CXCR4 and ACKR3 receptors and plays a physiological role in embryogenesis and haematopoiesis. It has an important role also in tumor development, since it is released by stromal cells of tumor microenvironment and alters the behavior of cancer cells. Many studies investigated the roles of CXCL12 in order to understand if it has an anti- or protumor role. In particular, it seems to promote tumor invasion, proliferation, angiogenesis, epithelial to mesenchymal transition (EMT), and metastasis in pancreatic cancer. Nevertheless, some evidence shows opposite functions; therefore research on CXCL12 is still ongoing. These discrepancies could be due to the presence of at least six CXCL12 splicing isoforms, each with different roles. Interestingly, three out of six variants have the highest levels of expression in the pancreas. Here, we report the current knowledge about the functions of this chemokine and then focus on pancreatic cancer. Moreover, we discuss the methods applied in recent studies in order to understand if they took into account the existence of the CXCL12 isoforms. |
| Databáze: | OpenAIRE |
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