Systematic review and meta-analysis of randomized controlled trials comparing botulinum toxin injection with lateral internal sphincterotomy for chronic anal fissure
| Autor: | Zhi-Kun Zhang, Wan-Jin Shao, Guo-Chun Li |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Botulinum Toxins medicine.medical_treatment Chronic anal fissure Urology Botulinum toxin injection law.invention Sphincterotomy Endoscopic Randomized controlled trial Recurrence law Internal medicine medicine Recurrent disease Humans Botulinum Toxins Type A Randomized Controlled Trials as Topic Wound Healing Anal fissure business.industry Gastroenterology Hepatology medicine.disease Surgery Treatment Outcome Meta-analysis Fissure in Ano business Lateral internal sphincterotomy |
| Zdroj: | International Journal of Colorectal Disease. 24:995-1000 |
| ISSN: | 1432-1262 0179-1958 |
| DOI: | 10.1007/s00384-009-0683-5 |
| Popis: | The aim of this review is to systematically analyze the prospective randomized controlled trials on the efficacy of botulinum toxin injection (Botox) vs. lateral internal sphincterotomy (LIS) for the treatment of chronic anal fissure (CAF). A systematic review of the literature was undertaken. The prospective randomized controlled trials on the effectiveness of Botox vs. LIS for the management of CAF were selected according to specific criteria and analyzed to generate pooling data. Four studies encompassing 279 patients were qualified for the meta-analysis. There was a statistically significant higher healing in LIS group compared with Botox group (RR 1.31[1.57, 1.50] 95% CI, z = 4.11, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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