Association of ICAM-1 gene variant rs5498 (1462AG) with non-obstructive azoospermia
| Autor: | Nervana Bayoumy, Mohamed M. El-Shabrawi, Hesham A. Nada |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Azoospermia
Non obstructive azoospermia Male ICAM-1 030219 obstetrics & reproductive medicine Genetic variants Obstetrics and Gynecology 030209 endocrinology & metabolism General Medicine Biology medicine.disease Intercellular Adhesion Molecule-1 Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Reproductive Medicine Case-Control Studies Cancer research medicine SNP Humans Spermatogenesis Intracellular |
| Zdroj: | Human fertility (Cambridge, England). 23(4) |
| ISSN: | 1742-8149 |
| Popis: | The blood testicular barrier (BTB) is a barrier protecting the testes from damage. It also plays an important role in spermatogenesis. The intracellular adhesion molecule-1 (ICAM-1) is a member of the immunoglobulin cell adhesion molecule family and is a constituent component of the BTB. This study was carried out to investigate the association between the single nucleotide polymorphism (SNP) rs5498 in the ICAM-1 gene and non-obstructive azoospermia. A total of 100 male patients with non-obstructive azoospermia and 100 fertile males (healthy control) were included in this study. Genotyping of ICAM-1 gene rs5498 was performed using polymerase chain reaction-restriction enzyme fragment length polymorphism (PCR-RFLP). Both AG and GG genotypes were significantly more prevalent among the infertile men compared to the control group ( |
| Databáze: | OpenAIRE |
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