Dietary chitosan enhances hepatic CYP7A1 activity and reduces plasma and liver cholesterol concentrations in diet-induced hypercholesterolemia in rats
| Autor: | Chong-Tai Kim, Yangha Kim, Min-Sun Moon, Mak-Soon Lee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
macromolecular substances Biology Cholesterol 7 alpha-hydroxylase Body weight Chitosan chemistry.chemical_compound Internal medicine medicine rat Cholesterol metabolism Original Research chemistry.chemical_classification Nutrition and Dietetics hypocholesterolemic Cholesterol Cholic acid technology industry and agriculture Liver cholesterol Endocrinology Enzyme chemistry CYP7A1 activity lipids (amino acids peptides and proteins) Food Science |
| Zdroj: | Nutrition Research and Practice |
| ISSN: | 2005-6168 1976-1457 |
| Popis: | The present study was performed to elucidate the hypocholesterolemic action of chitosan on the diet-induced hypercholesterolemia in rats. Male Sprague-Dawley rats (n=24) were fed with chitosan-free diet (Control), diets containing 2% or 5% chitosan for 4 weeks. Hypercholesterolemia was induced by adding 1% cholesterol and 0.5% cholic acid to all diets. Body weight gain and food intake of rats did not differ among the groups. The chitosan treated groups showed significant improvement in the plasma concentration of total cholesterol and LDL-cholesterol compared to the control group (p0.05). Also, the chitosan treated groups decreased the liver concentration of total lipid and total cholesterol compared to the control group (p0.05). The activity of hepatic cholesterol 7alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in the conversion of cholesterol to bile acids, was increased by 123% and 165% for the 2% or 5% chitosan diets, respectively. These findings suggest that enhancement of hepatic CYP7A1 activity may be a mechanism, which can partially account for the hypocholesterolemic effect of dietary chitosan in cholesterol metabolism. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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