Frequency of Thyroid Dysfunction in Patients With Diabetes Mellitus Before and After Liver Transplantation
| Autor: | E.C. de Ataide, Ticiane Gonçalez Bovi, Luciana Lot, A. Moura Neto, C.M. Righetto, Ilka de Fátima Santana Ferreira Boin, Adriana Russo Fiore, Simone Perales |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Population 030209 endocrinology & metabolism Liver transplantation Tacrolimus Diabetes Complications 03 medical and health sciences 0302 clinical medicine Postoperative Complications Interquartile range Risk Factors Diabetes mellitus Internal medicine medicine Diabetes Mellitus Prevalence Humans education Aged Retrospective Studies Transplantation education.field_of_study business.industry Thyroid Hypertriglyceridemia Retrospective cohort study Middle Aged medicine.disease Thyroid Diseases Liver Transplantation medicine.anatomical_structure 030211 gastroenterology & hepatology Surgery Female business Immunosuppressive Agents |
| Zdroj: | Transplantation proceedings. 50(3) |
| ISSN: | 1873-2623 |
| Popis: | Background There is mutual influence between the liver and thyroid hormone metabolism. Patients with diabetes mellitus (DM) also have an increased prevalence of thyroid disorders (TDs). The objectives of this study were to evaluate the frequency of TD before and after liver transplantation (LT) in a population of patients with DM as a whole and when categorized by sex. Materials and Methods This was a retrospective study involving interview and medical record analysis of 46 consecutive patients followed at the diabetes mellitus and liver transplantation unit of a tertiary university hospital. Results Of all patients, 76.1% were men with a median age of 60 years old (interquartile range: 56 to 65 years) and time since LT of 5 years (range, 0.6 to 9 years). Hypertension, hypercholesterolemia, hypertriglyceridemia, alcoholism, and smoking were present in 47.8%, 34.8%, 23.9%, 34.8%, and 30.4% of the patients, respectively. The most frequent immunosuppressant in use was tacrolimus (71.1%). TD was present in 4.3% and 13% before and after LT, respectively (P = .058). In women and men, these frequencies were 9.1% and 18.2% (P = .563), and 2.9% and 11.8% (P = .045), respectively. Conclusions Frequency of TD was high both before and after LT. After transplantation, prevalence of TD increased in men and differences between males and females almost disappeared. Further studies are needed to assess if screening for TD before and after LT in patients with DM might be beneficial, especially in men. |
| Databáze: | OpenAIRE |
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