| Autor: |
James S. Sharley, Guido Gambacorta, Ana María Collado Pérez, Estela Espinos Ferri, Amadeo Fernandez Miranda, Isabelle Fernández Fernández, Jorge Sanchez Quesada, Ian R. Baxendale |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Tetrahedron, 2022, Vol.126, pp.133068 [Peer Reviewed Journal] |
| ISSN: |
1556-5068 |
| DOI: |
10.2139/ssrn.4187023 |
| Popis: |
A new method for the oxidation of Hedione 1 to dehydrohedione 2, a high value intermediate in the flavour and fragrance industry, has developed based upon one pot α-chlorination-elimination sequence which can be readily scaled. The spontaneous elimination of the α-chloro in methanol was unprecedented and has allowed for the oxidation, typically performed in multiple steps/reactions, to be carried out as a one-pot protocol. A continuous flow process for performing the reaction utilising sulfuryl chloride has also demonstrated allowing for steady, safe evolution of SO2 gas during the reaction. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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