A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

Autor:	J. R. Heys, S. W. Landvatter, Joseph C. Lee, James E. Strickler, George P. Livi, Jerry L. Adams, Dean E. McNulty, Jeffrey T. Laydon, Sanjay Kumar, John R. White, I. R. Siemens, Timothy Gallagher, M. J. Blumenthal, David W. Green, Peter Young, Peter C. McDonnell, Megan M. McLaughlin, Seth M. Fisher
Rok vydání:	1994
Předmět:	DNA Complementary Pyridines Molecular Sequence Data MAPK7 MAP Kinase Kinase 3 Mitogen-activated protein kinase kinase Biology p38 Mitogen-Activated Protein Kinases Monocytes Cell Line Radioligand Assay Humans ASK1 Amino Acid Sequence Cloning Molecular Kinase activity Protein kinase A Multidisciplinary Base Sequence Tumor Necrosis Factor-alpha MAPKAPK2 Imidazoles Peptide Fragments Recombinant Proteins Biochemistry Calcium-Calmodulin-Dependent Protein Kinases Cytokines Chromosomes Human Pair 6 Cyclin-dependent kinase 9 Inflammation Mediators Mitogen-Activated Protein Kinases Interleukin-1
Zdroj:	Nature. 372:739-746
ISSN:	1476-4687 0028-0836
Popis:	Production of interleukin-1 and tumour necrosis factor from stimulated human monocytes is inhibited by a new series of pyridinyl-imidazole compounds. Using radiolabelled and radio-photoaffinity-labelled chemical probes, the target of these compounds was identified as a pair of closely related mitogen-activated protein kinase homologues, termed CSBPs. Binding of the pyridinyl-imidazole compounds inhibited CSBP kinase activity and could be directly correlated with their ability to inhibit cytokine production, suggesting that the CSBPs are critical for cytokine production.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24d7b582bf7042b4595ca6a9251e1cd https://doi.org/10.1038/372739a0 Zobrazit plný text záznamu