Mepivacaine alters vascular responsiveness to vasoconstrictors in aortic rings from normal and aortic-banded rats
| Autor: | Theodosios Saranteas, Christina Tesseromatis, Iordanis Mourouzis, Georgia Kostopanagiotou, Dennis V. Cokkinos, Constantinos Mourouzis, Constantinos Pantos, Chariclia Karageorgiou, Dennis Varonos |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Endothelium Health Toxicology and Mutagenesis Mepivacaine Stimulation Cardiomegaly Toxicology Muscle Smooth Vascular Potassium Chloride Phenylephrine medicine.artery Internal medicine medicine Animals Vasoconstrictor Agents Anesthetics Local Rats Wistar Aorta Pharmacology Chemistry Constriction Rats medicine.anatomical_structure Endocrinology cardiovascular system Endothelium Vascular medicine.symptom Vasoconstriction medicine.drug Blood vessel Muscle contraction |
| Zdroj: | Pharmacologytoxicology. 93(6) |
| ISSN: | 0901-9928 |
| Popis: | The present study investigated the effects of mepivacaine on the response of rat aorta to vasoconstrictors in normal and aortic-banded animals. Cardiac hypertrophy was induced in Wistar rats by aortic banding, while sham-operated animals served as controls. Isolated aortic rings with or without endothelium were contracted with potassium chloride and phenylephrine in the presence of mepivacaine (10−3 M). Maximal tension was measured at the highest concentration of potassium chloride and phenylephrine. Maximal response to potassium chloride was reduced in the presence of mepivacaine both in normal and aortic-banded rings. As regards the vascular reactivity to phenylephrine, aortic rings with intact endothelium from aortic-banded rats have shown increased response as compared to normal. After mepivacaine administration this difference between normal and aortic-banded rats was abolished. In conclusion, in a model of cardiac hypertrophy such as that of aortic-banding, increased response to α1-adrenergic stimulation is observed, which is blunted by mepivacaine administration. |
| Databáze: | OpenAIRE |
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