Diethyl sinapate-grafted cellulose nanocrystals as nature-inspired UV filters in cosmetic formulations
| Autor: | George P. Simon, Maisha Maliha, Florent Allais, Gil Garnier, Vikram Singh Raghuwanshi, Christine Browne, David Joram Mendoza, Louis M. M. Mouterde |
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| Přispěvatelé: | Bioresource Processing Research Institute of Australia (BioPRIA), Department of Chemical Engineering, Monash University [Clayton]-Monash University [Clayton], Agro-Biotechnologies Industrielles (ABI), AgroParisTech, Department of Materials Science and Engineering, Monash University [Clayton] |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Medicine (General)
DPPH QH301-705.5 Cytotoxicity Biomedical Engineering Nanoparticle Bioengineering 02 engineering and technology Cosmetics 010402 general chemistry 01 natural sciences Nanomaterials Humectant Biomaterials chemistry.chemical_compound R5-920 Full Length Article Glycerol UV-filters Biology (General) Diethyl sinapate Molecular Biology ComputingMilieux_MISCELLANEOUS Active ingredient Aqueous solution [CHIM.ORGA]Chemical Sciences/Organic chemistry Cellulose nanocrystals Cell Biology [CHIM.MATE]Chemical Sciences/Material chemistry 021001 nanoscience & nanotechnology Grafting 0104 chemical sciences chemistry Antioxidant 0210 nano-technology Biotechnology Nuclear chemistry |
| Zdroj: | Materials Today Bio Materials Today Bio, Elsevier, 2021, 12, pp.100126. ⟨10.1016/j.mtbio.2021.100126⟩ Materials Today Bio, Vol 12, Iss, Pp 100126-(2021) |
| ISSN: | 2590-0064 |
| Popis: | Inspired by nature’s photoprotection mechanisms, we report an effective UV-blocking nanomaterial based on diethyl sinapate-grafted cellulose nanocrystals (CNC-DES). The colloidal stability and UV-blocking performance of CNC-DES in aqueous glycerol (a common humectant in petroleum-free cosmetic formulations) and in a commercially available moisturizing cream were studied. Grafting the water-insoluble DES onto CNCs renders it dispersible in these water-based formulations, thanks to the excellent water-dispersibility of CNC nanoparticles. Glycerol dispersions containing 0.1 to 1.5 wt% CNC-DES display very high UV-blocking activity owing to the anti-UV DES moieties anchored onto CNCs. A facial cream blended with 1.5 wt% CNC-DES exhibits an SPF of 5.03, which is higher than a commercially available sunscreen with the same active ingredient concentration (SPF = 3.84). DPPH radical scavenging assay also showed the antioxidant potential of CNC-DES, albeit coinciding with a significant reduction in antioxidant activity after grafting DES onto CNCs. Cytotoxicity measurements revealed the CNC-DES not to cause significant cytotoxicity to murine fibroblast cells after 24 h of exposure. Overall, CNC-DES exhibits strong anti-UV and antioxidant properties and is water-dispersible, biocompatible, non-greasy, and lightweight. This study demonstrates the exceptional potential of DES-grafted CNCs as nature-inspired UV filters in the next generation of cosmetic formulations, including those for sensitive skins. Graphical abstract In this work, diethyl sinapate-grafted CNCs (CNC-DES) was explored as potential UV filters in cosmetic formulations. Grafting the water-insoluble DES onto the water-dispersible CNCs increases its dispersibility in aqueous glycerol and a commercially available oil-free moisturizing cream. CNC-DES exhibits strong anti-UV and antioxidant properties and is water-dispersible, biocompatible, non-greasy, and lightweight.Image 1 |
| Databáze: | OpenAIRE |
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