FMRF-NH2-like factor from neurohaemal organ modulates neuromuscular transmission in the locust
| Autor: | Chr. Walther, Michael Schiebe |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
medicine.medical_specialty
Contraction (grammar) biology General Neuroscience Enkephalin Methionine Neuropeptides Neuromuscular transmission Neuropeptide Endogeny Grasshoppers biology.organism_classification Neurosecretory Systems Synaptic Transmission Endocrinology Internal medicine medicine Biophysics Animals FMRFamide medicine.symptom Muscle fibre Octopamine Locust Muscle contraction |
| Zdroj: | Neuroscience letters. 77(2) |
| ISSN: | 0304-3940 |
| Popis: | YGGFMRFamide, FMRFamide and related peptides potentiate transmission at locust slow motor synapses. Since immunohistochemical evidence points to neurohaemal organs (NHO) as potential sources for endogenous RFamide-like peptides we have applied extracts from the metathoracic NHO, equivalent to 1 3 NHO, to the metathoracic extensor tibiae muscle. NHO-extract (1) depolarizes the muscle fibre and increases its membrane resistance; (2) enhances transmitter release; and (3) increases the amplitude of contraction and the rate of relaxation. These effects are in good qualitative and quantitative agreement with those of YGGFMRFamide (5 × 10−8 to 10−7 M). Octopamine which partly acts like YGGFMRFamide cannot account for the NHO-effects. |
| Databáze: | OpenAIRE |
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