Crystallography-Guided Optimizations of the Keap1–Nrf2 Inhibitors on the Solvent Exposed Region: From Symmetric to Asymmetric Naphthalenesulfonamides

Autor:	Guodong Liu, Ruilin Hou, Lijuan Xu, Xinqi Zhang, Jianyu Yan, Chengguo Xing, Ke Xu, Chunlin Zhuang
Rok vydání:	2022
Předmět:	Sulfonamides Crystallography Kelch-Like ECH-Associated Protein 1 NF-E2-Related Factor 2 Drug Discovery Solvents Humans Molecular Medicine Protein Binding
Zdroj:	Journal of Medicinal Chemistry. 65:8289-8302
ISSN:	1520-4804 0022-2623
DOI:	10.1021/acs.jmedchem.2c00170
Popis:	Directly inhibiting the Keap1-Nrf2 protein-protein interaction has been investigated as a promising strategy to activate Nrf2 for anti-inflammation. We previously reported a naphthalensulfonamide Keap1-Nrf2 inhibitor
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24772348ce58f2310038a06545a3988 https://doi.org/10.1021/acs.jmedchem.2c00170 Zobrazit plný text záznamu