Sigma-1 antagonism inhibits binge ethanol drinking at adolescence
| Autor: | Leandro Ruiz-Leyva, Agustín Salguero, Enrique Portillo-Salido, Ignacio Morón, Ricardo Marcos Pautassi, Cruz Miguel Cendán |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Alcohol Drinking Binge drinking Female adolescent Toxicology Binge Drinking 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Binge ethanol Animals Humans Receptors sigma Medicine Pharmacology (medical) 030212 general & internal medicine Rats Wistar Novel object recognition Pharmacology Ethanol business.industry Ethanol drinking Rats Psychiatry and Mental health Endocrinology chemistry Female Ethanol intake Antagonism business 030217 neurology & neurosurgery |
| Zdroj: | Drug and Alcohol Dependence. 215:108214 |
| ISSN: | 0376-8716 |
| Popis: | Background Ethanol use during adolescence is a significant health problem, yet the pharmacological treatments to reduce adolescent binge drinking are scarce. The present study assessed, in male and female adolescent Wistar rats, if the sigma-1 receptor (S1-R) antagonists S1RA or BD-1063 disrupted ethanol drinking. Methods Three times a week, for two weeks, the rats received the S1-R antagonists. Thirty min later they were exposed, for 2 h, to a bottle of 8% or 10 % v/v ethanol. A 24 h, two-bottle, ethanol intake test was conducted after termination of these procedures. A subset of these rats was tested for recognition memory via the novel object recognition test. Results The rats given 64 mg/kg S1RA drank, in each binge session, significantly less than vehicle counterparts. Male rats given 4 or 16 mg/kg S1RA drank significantly less than those given 0 mg/kg in session 3 or in session 1 and 2, respectively; whereas female rats given 4 or 16 mg/kg drank significantly less than females given 0 mg/kg in session 2–5 or in sessions 2–6, respectively. Administration of 32 mg/kg, but not of 2 or 8 mg/kg, BD-1063 suppressed, across sessions, ethanol drinking. S1-R antagonism reduced absolute ethanol drinking at the two-bottle choice post-test. Recognition memory was not affected by the ethanol exposure. Conclusions The results indicate that S1-R antagonists may be promising targets to prevent increases in ethanol intake at adolescence. The persistent effect of S1-R antagonism in free-choice drinking suggests that modulation of the S1-R is altering plastic effects associated with ethanol exposure. |
| Databáze: | OpenAIRE |
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