| Autor: |
David A. G. Chapman, Haru-H. Takamatsu, Geoff Hutchings, Christopher L. Netherton, Jordi Argilaguet, C.A.L. Oura, Evelyne Hutet, Emma Fishbourne, Roland Cariolet, Katherine King, Katy Moffat, Marie-Frédérique Le Potier, Geraldine Taylor, Linda K. Dixon |
| Jazyk: |
angličtina |
| Předmět: |
|
| Zdroj: |
Vaccine |
| ISSN: |
0264-410X |
| DOI: |
10.1016/j.vaccine.2011.04.052 |
| Popis: |
African swine fever (ASF) is an acute haemorrhagic disease of domestic pigs for which there is currently no vaccine. We showed that experimental immunisation of pigs with the non-virulent OURT88/3 genotype I isolate from Portugal followed by the closely related virulent OURT88/1 genotype I isolate could confer protection against challenge with virulent isolates from Africa including the genotype I Benin 97/1 isolate and genotype X Uganda 1965 isolate. This immunisation strategy protected most pigs challenged with either Benin or Uganda from both disease and viraemia. Cross-protection was correlated with the ability of different ASFV isolates to stimulate immune lymphocytes from the OURT88/3 and OURT88/1 immunised pigs. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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