Kidney transplantation from small pediatric donors may be feasible to those who developed chronic refractory dialysis hypotension: a single-center experience
| Autor: | Rending Wang, Yu Cui, Wenhua Lei, Wenhan Peng, Junhao Lv, Lu Zheng, Jianghua Chen, Jianyong Wu, Guangjun Liu, Hanying Jia |
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| Rok vydání: | 2020 |
| Předmět: |
Creatinine
medicine.medical_specialty business.industry 030232 urology & nephrology Renal function General Medicine 030204 cardiovascular system & hematology medicine.disease Single Center Group B Surgery Transplantation 03 medical and health sciences chemistry.chemical_compound surgical procedures operative 0302 clinical medicine Blood pressure chemistry Refractory medicine Original Article business Kidney transplantation |
| Zdroj: | Ann Transl Med |
| ISSN: | 2305-5847 2305-5839 |
| DOI: | 10.21037/atm-20-304 |
| Popis: | Background Chronic refractory dialysis hypotension (CRDH) is a serious issue in dialysis patients waiting for transplants. It leads to fatal clinical outcomes and disqualification from kidney transplantation. Kidney transplantation from pediatric donor to adult patient with lower blood pressure (BP) may be an option. No related study has been reported and we conducted this study to first evaluate the effect of pediatric donor kidney transplantation in CRDH recipients. Methods Ten single-kidney transplantations from small pediatric donors after cardiac death in our center between August 2016 and April 2018 were described. Half were CRDH recipients (group A) with intradialytic and interdialytic systolic blood pressure (SBP) below 100 mmHg. Each was paired with no-CRDH recipient (control, group B) from the same donor. The operation method of vascular anastomosis and ureterocystoneostomy was the same as that of adult donors. Clinical characteristics, post-operative treatment and outcomes of all recipients were retrieved. Postoperative BP, graft function and size were compared between two groups. The follow-up time was up to April 2019. Results There was no acute rejection (AR), graft loss or death in all recipients after transplantation. Their renal function was recovered despite three transient delayed graft function (DGF). There was no significant difference in serum creatinine (SCr) or graft size (P=0.84, 0.94) after transplantation between two groups. For all CRDH recipients, the postoperative SBP was above 100 mmHg (except one, 90-130 mmHg). The BP one year after transplantation was maintained at 110-125/70-85 mmHg. Conclusions kidney transplantation from small pediatric donors may be feasible to CRDH recipients and their BP may return to normal after transplantation. |
| Databáze: | OpenAIRE |
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