Integrated Analysis of Pharmacokinetic Data Across Multiple Clinical Pharmacology Studies of Prasugrel, a New Thienopyridine Antiplatelet Agent
| Autor: | David S. Small, C. Steven Ernest, Kenneth J. Winters, Nagy A. Farid, Shashank Rohatagi, Christopher D. Payne, John H. April, Ying G. Li, Lan Ni |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Prasugrel Adolescent Thienopyridine Thiophenes Models Biological Piperazines law.invention Young Adult Pharmacokinetics law Internal medicine medicine Humans Prodrugs Pharmacology (medical) Dosing Acute Coronary Syndrome Young adult Biotransformation Aged Aged 80 and over Pharmacology Clinical pharmacology Prasugrel Hydrochloride business.industry Body Weight Middle Aged Receptors Purinergic P2Y12 Clinical trial Anesthesia Purinergic P2Y Receptor Antagonists Female business Platelet Aggregation Inhibitors Half-Life medicine.drug |
| Zdroj: | The Journal of Clinical Pharmacology. 51:321-332 |
| ISSN: | 0091-2700 |
| Popis: | An integrated analysis of pharmacokinetic (PK) parameter estimates for prasugrel, from 16 phase I clinical pharmacology studies, consolidated exposure estimates from 506 healthy male and female participants and evaluated the effect of specific intrinsic and extrinsic factors on exposure to prasugrel's active metabolite (AM, R-138727). A linear mixed effect model was fitted with study and subject nested within study as random effects and subject factors as fixed effects. Prasugrel AM exposure was similar in males and females, in participants |
| Databáze: | OpenAIRE |
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