Heart rate variability response to mental arithmetic stress is abnormal in first-degree relatives of individuals with schizophrenia
| Autor: | Salvador M. Guinjoan, Delfina de Achával, Rodolfo D. Fahrer, Elvina M. Chu, Ramón Leiguarda, Daniel P. Cardinali, Daniel Eduardo Vigo, Mariana N. Castro, Elsa Y. Costanzo, Martin Nogues |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Psychosis STRESS CIENCIAS MÉDICAS Y DE LA SALUD Adolescent Neurociencias Hemodynamics Medicina Clínica Autonomic Nervous System Heart Rate Internal medicine Heart rate SCHIZOPHRENIA medicine Heart rate variability Humans Family First-degree relatives Psychiatry Biological Psychiatry Depression (differential diagnoses) Problem Solving Psiquiatría Aged ENDOPHENOTYPES Heart Middle Aged medicine.disease HEART RATE VARIABILITY AUTONOMIC NERVOUS SYSTEM Psychiatry and Mental health Autonomic nervous system Medicina Básica Schizophrenia Cardiology Female Schizophrenic Psychology Psychology Mathematics Stress Psychological |
| Popis: | Background: Schizophrenia patients exhibit an abnormal autonomic response to mental stress. We sought to determine the cardiac autonomic response to mental arithmetic stress in their unaffected first-degree relatives. Methods: Heart rate variability (HRV) analysis was performed on recordings obtained before, during, and after a standard mental arithmetic task to induce mental stress. 22 unaffected first-degree relatives of patients meeting DSM-IV criteria for schizophrenia (R) and 22 healthy individuals (C) were included in this study. Results: Patients' relatives (R) had a normal response to the mental arithmetic stress test, showing an increased heart rate compared with controls. They also displayed the characteristic pattern of relative contributions of HRV components that consists of increased low-frequency (LF) HRV and decreased high-frequency (HF) HRV. Recovery of the resting pattern of HRV immediately after stress termination was observed in healthy subjects (LF 62 ± 16% vs. 74 ± 10%, HF 37 ± 16% vs. 25 ± 10%, F = 9.616, p = 0.004), but not in patients' relatives (LF 60 ± 19% vs. 70 ± 13%, HF 40 ± 19% vs. 29 ± 13%, F = 8.4, p = 0.056). Conclusions: First-degree relatives of schizophrenia patients exhibit an abnormal pattern of protracted response to mental arithmetic stress, though less intense than that observed in patients in a previous study. This suggests that a pattern of autonomic response to stress may therefore be familial and heritable. Fil: Castro, Mariana Nair. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Vigo, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina Fil: Chu, Elvina. University College London; Estados Unidos Fil: Fahrer, Rodolfo D.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina Fil: de Achával, Delfina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina Fil: Costanzo, Elsa Y.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina Fil: Leiguarda, Ramón Carlos. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina Fil: Nogués, Martín. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina Fil: Cardinali, Daniel Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina Fil: Guinjoan, Salvador Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina |
| Databáze: | OpenAIRE |
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