Genetic variations in VEGF and VEGFR2 and glioblastoma outcome

Autor: Sara Sjöström, Yufei Liu, Christoffer Johansen, Roger Henriksson, Helle Broholm, Thomas Brännström, Beatrice Melin, Carl Wibom, Helle Collatz-Laier, Ulrika Andersson, Melissa L. Bondy
Rok vydání: 2010
Předmět:
Adult
Male
Vascular Endothelial Growth Factor A
Oncology
Cancer Research
medicine.medical_specialty
Survival
Genotype
Glioblastoma outcome
Clinical Neurology
Single-nucleotide polymorphism
Biology
Polymerase Chain Reaction
Polymorphism
Single Nucleotide
Young Adult
chemistry.chemical_compound
Internal medicine
Genetic variation
Biomarkers
Tumor
medicine
Humans
Genetic Predisposition to Disease
Genetic variability
Receptor
Aged
Brain Neoplasms
Vascular endothelial growth factor (VEGF)
Kinase insert domain receptor
Middle Aged
Prognosis
Vascular Endothelial Growth Factor Receptor-2
Association study
Vascular endothelial growth factor
Vascular endothelial growth factor A
Clinical Study – Patient Study
Neurology
chemistry
Spectrometry
Mass
Matrix-Assisted Laser Desorption-Ionization
Immunology
cardiovascular system
Female
Neurology (clinical)
Glioblastoma
Vascular endothelial growth factor receptor (VEGFR)
Zdroj: Journal of Neuro-Oncology
ISSN: 1573-7373
0167-594X
Popis: Vascular endothelial growth factor (VEGF) and its receptors (VEGFR) are central components in the development and progression of glioblastoma. To investigate if genetic variation in VEGF and VEGFR2 is associated with glioblastoma prognosis, we examined blood samples from 154 glioblastoma cases collected in Sweden and Denmark between 2000 and 2004. Seventeen tagging single nucleotide polymorphisms (SNPs) in VEGF and 27 in VEGFR2 were genotyped and analysed, covering 90% of the genetic variability within the genes. In VEGF, we found no SNPs associated with survival. In VEGFR2, we found two SNPs significantly associated to survival, namely rs2071559 and rs12502008. However, these results are likely to be false positives due to multiple testing and could not be confirmed in a separate dataset. Overall, this study provides little evidence that VEGF and VEGFR2 polymorphisms are important for glioblastoma survival.
Databáze: OpenAIRE
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