Harlequin Ichthyosis in Two Greater Kudu (Tragelaphus strepsiceros)
Autor: | Thierry Olivry, E. J. Chittick, F. Dalldorf, B. A. Wolfe, J. Wright, B. A. Dale |
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Rok vydání: | 2002 |
Předmět: |
Male
0301 basic medicine Pathology medicine.medical_specialty 040301 veterinary sciences Lamellar granule 0403 veterinary science Lesion 03 medical and health sciences Fatal Outcome medicine Animals Parakeratosis General Veterinary biology Histocytochemistry Ectropion 04 agricultural and veterinary sciences Anatomy Harlequin Ichthyosis biology.organism_classification medicine.disease Orthokeratosis Tragelaphus strepsiceros Microscopy Electron Eclabium 030104 developmental biology Antelopes Cattle Female medicine.symptom Ichthyosis Lamellar |
Zdroj: | Veterinary Pathology. 39:751-756 |
ISSN: | 1544-2217 0300-9858 |
DOI: | 10.1354/vp.39-6-751 |
Popis: | Two greater kudu calves (Tragelaphus strepsiceros) born 7 years apart were found with fissures and thickened, scaly, cutaneous plates covering over 80% of their bodies. One was dead at presentation, and the other was euthanized shortly after birth. Both animals shared a common sire. On necropsy, chemosis, ectropion, eclabium, and bilateral valgus deformities of the tarsal joints were observed in one calf, presumed to be secondary to the plates restricting normal fetal development. The principal microscopic lesion was severe lamellar orthokeratosis, with focal mild parakeratosis. Ultrastructural epidermal lesions included the absence of normal lamellar granules, large dilated endoplasmic reticulum, and abnormal retention of organelles and vesicles. Gross, histopathologic, and electron microscopic findings in both kudu calves were consistent with those of harlequin ichthyosis, a rare dermatosis of humans believed to have an autosomal recessive inheritance pattern. The underlying genetic and molecular abnormality and heritability of this condition in this greater kudu herd were not determined. |
Databáze: | OpenAIRE |
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