Behavioral cost & overdominance in Anopheles gambiae

Autor: Malal Mamadou Diop, Pascal Milesi, Pierrick Labbé, Cédric Pennetier, Stéphane Duchon, Fabrice Chandre, Olayidé Boussari, Angélique Porciani, Hadrien Martin-Herrou, Nicolas Moiroux
Přispěvatelé: Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Vector Control Group (MIVEGEC-VCG), Evolution des Systèmes Vectoriels (ESV), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Departamento de Ecología, Genética y Evolución [Buenos Aires] (EGE), Facultad de Ciencias Exactas y Naturales [Buenos Aires] (FCEyN), Universidad de Buenos Aires [Buenos Aires] (UBA)-Universidad de Buenos Aires [Buenos Aires] (UBA), Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE)
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Insecticides
Mosquito Control
Anopheles gambiae
Mutation
Missense
lcsh:Medicine
Overdominance
Voltage-Gated Sodium Channels
Biology
Insecticide Resistance
chemistry.chemical_compound
[SDV.EE.ECO]Life Sciences [q-bio]/Ecology
environment/Ecosystems
Anopheles
parasitic diseases
medicine
Animals
Humans
lcsh:Science
Permethrin
Genes
Dominant
Genetics
Mosquito Nets
Multidisciplinary
Pyrethroid
[SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE]
[SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE]
lcsh:R
fungi
Heterozygote advantage
Feeding Behavior
biology.organism_classification
[SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM]
Insect Vectors
3. Good health
Mosquito control
chemistry
Mutation (genetic algorithm)
Insect Proteins
lcsh:Q
Female
Research Article
medicine.drug
Zdroj: PLoS ONE
PLoS ONE, Public Library of Science, 2015, 10 (4), ⟨10.1371/journal.pone.0121755⟩
PLoS ONE, Vol 10, Iss 4, p e0121755 (2015)
PLoS ONE, 2015, 10 (4), ⟨10.1371/journal.pone.0121755⟩
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0121755⟩
Popis: International audience; In response to the widespread use of control strategies such as Insecticide Treated Nets (ITN), Anopheles mosquitoes have evolved various resistance mechanisms. Kdr is a mutation that provides physiological resistance to the pyrethroid insecticides family (PYR). In the present study, we investigated the effect of the Kdr mutation on the ability of female An. gambiae to locate and penetrate a 1cm-diameter hole in a piece of netting, either treated with insecticide or untreated, to reach a bait in a wind tunnel. Kdr homozygous, PYR-resistant mosquitoes were the least efficient at penetrating an untreated damaged net, with about 51% [39-63] success rate compared to 80% [70-90] and 78% [65-91] for homozygous susceptible and heterozygous respectively. This reduced efficiency, likely due to reduced host-seeking activity, as revealed by mosquito video-tracking, is evidence of a recessive be-havioral cost of the mutation. Kdr heterozygous mosquitoes were the most efficient at penetrating nets treated with PYR insecticide, thus providing evidence for overdominance, the rarely-described case of heterozygote advantage conveyed by a single locus. The study also highlights the remarkable capacity of female mosquitoes, whether PYR-resistant or not, to locate holes in bed-nets.
Databáze: OpenAIRE
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