Prevalence of HBV genotypes in Central and Eastern Europe

Autor: Markus Cornberg, Michael P. Manns, Ivica Grgurević, Janusz Slusarczyk, Krzysztof P. Bielawski, Adriana Vince, Thomas Bock, Marcela Drazdakova, Mária Takács, Johannes Wiegand, Janusz Stanczak, Ileana Constantinescu, Filofteia Daniela Nedelcu, Heiner Wedemeyer, J. Gervain, Otakar Srtunecky, Katja Deterding, Vratislav Nemecek, Arvydas Ambrozaitis, Vladimir Chulanov, Małgorzata Zalewska
Rok vydání: 2008
Předmět:
Zdroj: Journal of Medical Virology. 80:1707-1711
ISSN: 1096-9071
0146-6615
DOI: 10.1002/jmv.21294
Popis: The importance of hepatitis B virus (HBV) genotypes for disease progression and response to interferon-alpha-based treatment is well established. While almost all patients in the Mediterranean area are infected with HBV genotype D, HBV genotype A is dominant in Northern Europe. However, the distribution of HBV genotypes is unknown for several Central and Eastern European countries. Data are described of 1313 HBsAg-positive patients recruited at 14 referral centers in eight countries. There were only very few cases of HBV genotype B, C, E, F, and H infection while HBV genotypes A and D were found in 42% and 48% of patients, respectively. Eight percent of patients had positive bands for more than one genotype using the hybridization assay. The frequency of genotype A was higher in Poland (77%) and the Czech Republic (67%) as compared to Hungary (47%), Lithuania (41%), Croatia (8%), and Germany (32%). In contrast, HBV genotype D was most frequent in Croatian, Romanian, and Russian patients with 80%, 67%, and 93% of cases, respectively. In conclusion, HBV genotype A versus D showed significantly different distribution patterns in Central and Eastern Europe which deserves consideration for national guidelines and treatment decisions.
Databáze: OpenAIRE
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