The Significance of Family History in First-Episode Schizophrenia Spectrum Disorder
Autor: | Sandra Northcott, Rahul Manchanda, Raj Harricharan, Ross M.G. Norman, Ashok Malla |
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Rok vydání: | 2007 |
Předmět: |
Psychosis
medicine.medical_specialty Sex Factors Borderline intellectual functioning mental disorders medicine Humans Family Spectrum disorder Age of Onset First-degree relatives Family history Psychiatry Family Health Intelligence Tests Ontario Psychiatric Status Rating Scales First episode Electroencephalography Cognition medicine.disease Diagnostic and Statistical Manual of Mental Disorders Psychiatry and Mental health Treatment Outcome Schizophrenia Schizophrenic Psychology Psychology Social Adjustment Antipsychotic Agents Follow-Up Studies Clinical psychology |
Zdroj: | Journal of Nervous & Mental Disease. 195:846-852 |
ISSN: | 0022-3018 |
Popis: | There have been inconsistent findings regarding the significance of family history of schizophrenia spectrum disorders in relation to presentation and course of illness. There has been little research relevant to this issue from first-episode patients. We examined the differences in premorbid adjustment, symptoms, and intellectual functioning between 28 first-episode schizophrenia spectrum patients with a history of such illness in first degree relatives and 28 matched patients without such a family history. The results indicate that whereas the 2 groups did not differ in presenting symptoms, those with a positive family history showed poorer intellectual functioning and less reduction in symptoms at 2 and 3 year follow-up and greater likelihood of abnormal electroencephalogram findings. The findings provide evidence that presence of a positive family history in first-episode patients is associated with a more pernicious form of illness. |
Databáze: | OpenAIRE |
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