One-Pot Conversion of β-Aminocrotononitrile to Secondary Enaminonitriles Including Chiral Ones — Application to Synthesis

Autor:	S. K. Dutta Chowdhury, Manisha Mishra, Asima Chatterjee, Kumar K. Mahalanabis
Rok vydání:	2006
Předmět:	Chemistry Organic Chemistry Organic chemistry General Chemistry General Medicine Combinatorial chemistry Catalysis
Zdroj:	ChemInform. 37
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200614053
Popis:	A highly efficient one-pot conversion of β-aminocrotononitrile to secondary enaminonitriles including chiral ones is described. In contrast to β-aminocrotononitrile, some of these N-substituted β-enaminonitriles on reacting with acid chlorides show a unique preference for C-terminal selection allowing preparation of pyrazoles without separation of regioisomers. In addition, use of secondary enaminonitriles also provided access to pyrazoles that are not obtainable with primary enaminonitriles owing to an exclusive preference for N-terminal selection.Key words: β-aminocrotononitrile, N-substituted enaminonitriles, regioselective, pyrazoles.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23f4ca6f288e186228c11495b49bf0a https://doi.org/10.1002/chin.200614053 Zobrazit plný text záznamu Plný text