The p53 Family Protein p73 Provides New Insights into Cancer Chemosensitivity and Targeting

Autor: Paolo Lunghi, Antonio Bonati, Vittorio Rizzoli, Antonio Costanzo, Massimo Levrero, Laura Mazzera
Rok vydání: 2009
Předmět:
Cancer Research
Programmed cell death
Mutation
Tumor Suppressor Protein p53
Neoplasms
Tumor Suppressor Proteins
Drug Delivery Systems
DNA-Binding Proteins
Humans
Apoptosis
Nuclear Proteins
Protein Isoforms
Drug Resistance
Neoplasm
Models
Biological
Drug Design
Mutant
Drug Resistance
Biology
medicine.disease_cause
Models
medicine
Tumor Protein p73
skin and connective tissue diseases
neoplasms
Genetics
Settore MED/35 - Malattie Cutanee e Veneree
Cancer
Apoptosis
DNA-Binding Proteins
antagonists /&/ inhibitors/metabolism
Drug Delivery Systems
Drug Design
Drug Resistance
Neoplasm
Humans
Models
Biological
Mutation
Neoplasms
dr/ug therapy/metabolism
Nuclear Proteins
antagonists /&/ inhibitors/metabolism
Protein Isoforms
metabolism
Tumor Suppressor Protein p53
metabolism
Tumor Suppressor Proteins
antagonists /&/ inhibitors/metabolism
Biological
medicine.disease
Oncology
Acetylation
Cancer research
Neoplasm
Phosphorylation
Zdroj: Clinical Cancer Research. 15:6495-6502
ISSN: 1557-3265
1078-0432
Popis: The p53 tumor suppressor is part of a small family of related proteins that includes two other members, p73 and p63. Interest in the p53 family members, their functions and their complex interactions and regulation, has steadily grown over recent years and does not show signs of waning. p73 is a major determinant of chemosensitivity in humans, and mutant p53 proteins carrying specific polymorphisms can induce drug resistance by inhibiting TAp73. Cooperation between TA (transactivating, proapoptotic, antiproliferative) and ΔN (truncated, antiapoptotic, pro-proliferative) p73 isoforms and among the three family members guarantees equilibrium between proliferation, differentiation, and cell death, thus creating a harmony that is lost in several human cancers. In this article, we review our current knowledge of the role of p73 in cancer chemosensitivity and the real prospect of therapy targeting this molecule. We also draw attention to the crucial role of specific phosphorylation and acetylation events for p73-induced apoptosis and drug chemosensitivity. (Clin Cancer Res 2009;15(21):6495–502)
Databáze: OpenAIRE
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