Clinicopathological significance of 'subtypes with stem-cell feature' in combined hepatocellular-cholangiocarcinoma
| Autor: | Yuko Kakuda, Motoko Sasaki, Yasuni Nakanuma, Joon Hyuk Choi, Hirohide Sato, Yasunori Sato |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Stromal cell Carcinoma Hepatocellular Inflammation Biology Cholangiocarcinoma Fibrosis medicine Humans Progenitor cell Grading (tumors) Aged Retrospective Studies Aged 80 and over Hepatology Mucin Liver Neoplasms Middle Aged medicine.disease Immunohistochemistry Bile Duct Neoplasms Liver Hepatocellular carcinoma Neoplastic Stem Cells Female medicine.symptom |
| Zdroj: | Liver international : official journal of the International Association for the Study of the Liver. 35(3) |
| ISSN: | 1478-3231 |
| Popis: | Backgrounds & Aims Combined hepatocellular-cholangiocarcinoma (cHC-CC), a malignant liver tumour with poor prognosis, is composed of hepatocellular carcinoma (HCC), cholangiocarcinoma (CC) and diverse components with intermediate features between HCC and CC, which correspond to hepatic progenitor cells. According to the WHO classification 2010, we surveyed the prevalence and clinicopathological significance of each subtype with stem-cell features [SC subtype; typical subtype (TS), intermediate cell subtype (INT) and cholangiolocellular type (CLC)] in cHC-CC and HCC. Methods Sixty-two patients with cHC-CC (19 women and 43 men) and 26 patients with HCC (all men) were examined. The prevalence of each component was histologically assessed with assistance of mucin and immunohistochemical stainings. Results SC subtypes were observed in all cHC-CCs in various amount and combination. The prevalence of each SC subtype in cHC-CC was as follows: TS, 10 (16.1%); INT, 53 (83.9%) and CLC, 44 (71.0%). The proportion of INT was significantly correlated with gender (female-dominant) (P |
| Databáze: | OpenAIRE |
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