Epstein‐Barr Virus and Human Herpesvirus 8 Prevalence in Human Immunodeficiency Virus‐Associated Oral Mucosal Lesions
| Autor: | Rachel Hood Edwards, Lauren L. Patton, Nancy Raab-Traub, David A. Wohl, Evelyn B. Quinlivan, Jennifer Webster-Cyriaque |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Hairy leukoplakia Herpesvirus 4 Human Simplexvirus Leukoplakia Hairy food.ingredient viruses medicine.disease_cause Polymerase Chain Reaction Virus Herpesviridae food hemic and lymphatic diseases medicine Humans Immunology and Allergy Gammaherpesvirinae Cloning Molecular Sarcoma Kaposi Lymphoma AIDS-Related Repetitive Sequences Nucleic Acid Leukoplakia Mouth neoplasm AIDS-Related Opportunistic Infections biology Mouth Mucosa virus diseases Herpesviridae Infections Sequence Analysis DNA medicine.disease biology.organism_classification Epstein–Barr virus Virology Tumor Virus Infections stomatognathic diseases Infectious Diseases DNA Viral Herpesvirus 8 Human Immunology Mouth Diseases |
| Zdroj: | The Journal of Infectious Diseases. 175:1324-1332 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/516463 |
| Popis: | The prevalence of Epstein-Barr virus (EBV) and the recently identified Kaposi's sarcoma (KS)-associated herpesvirus (also designated human herpesvirus 8 [HHV-8]) was determined in oral lesions and oral neoplasms common to persons with human immunodeficiency virus (HIV) infection. Oral lesions were examined by polymerase chain reaction (PCR) for EBV and HHV-8 DNA and by Southern blot analysis for EBV clonality. EBV was detected by Southern blot in hairy leukoplakia lesions, in a subset of AIDS-related lymphomas, and in saliva from HIV-positive persons but not in pseudohairy leukoplakia lesions, oral aphthous ulcers, or oral KS lesions. EBV was detected, however, by PCR in most of the lesions, while HHV-8 was detected only in oral KSs. The absence of HHV-8 DNA in both the EBV-associated hairy leukoplakia lesions and in the EBV-associated AIDS-related lymphomas strengthens the etiologic relationship of EBV to these pathologies and the etiologic role of HHV-8 in KS. |
| Databáze: | OpenAIRE |
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