Effects of Non-thermal, Non-cavitational Ultrasound Exposure on Human Diabetic Ulcer Healing and Inflammatory Gene Expression in a Pilot Study
| Autor: | Peter A. Lewin, Michael S. Weingarten, Kara L. Spiller, Anamika Bajpai, Michael Neidrauer, Sumati Nadkarni |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Chronic wound medicine.medical_specialty Acoustics and Ultrasonics Ultrasonic Therapy Biophysics Gene Expression Pilot Projects Inflammation Diabetic ulcers Article 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Internal medicine Humans Medicine Radiology Nuclear Medicine and imaging Lead (electronics) Inflammatory genes Wound Healing Radiological and Ultrasound Technology business.industry Ultrasound Middle Aged medicine.disease Diabetic foot Diabetic Foot Treatment Outcome 030104 developmental biology Ultrasonic Waves Female medicine.symptom business Wound healing |
| Zdroj: | Ultrasound in Medicine & Biology. 44:2043-2049 |
| ISSN: | 0301-5629 |
| DOI: | 10.1016/j.ultrasmedbio.2018.05.011 |
| Popis: | The purpose of this clinical study was to assess, in a limited patient population, the potential for a novel advanced wound care treatment based on low intensity, low frequency ultrasound (LFLI-US) to affect wound closure rate in human diabetic foot ulcers (DFU) and to effect changes in the relative expression of pro-inflammatory and anti-inflammatory genes. The ratio of expression of these genes, termed the M1/M2 score because it was inspired by the transition of macrophages from pro-inflammatory (M1) to anti-inflammatory (M2) phenotypes as wound healing progresses, was previously presented as a potential healing indicator for DFUs treated with the standard of care (Nassiri et al. 2015). We have also shown that noncavitational, nonthermal, low frequency (20 kHz), low intensity (spatial peak temporal peak intensity |
| Databáze: | OpenAIRE |
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