Chemical composition, antioxidant and macromolecule damage protective effects of Picrorhiza kurroa Royle ex Benth
| Autor: | K. Hemanth Kumar, G.V. Jayashree, K. Krupashree, P. Rachitha, Farhath Khanum |
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| Rok vydání: | 2014 |
| Předmět: |
Antioxidant
Traditional medicine biology Chemistry DPPH medicine.medical_treatment Picrorhiza kurroa Iridoid Glucosides Plant Science Protein oxidation Lipid peroxidation chemistry.chemical_compound Biochemistry Oxidative stress medicine biology.protein Vanillic acid DNA damage Bovine serum albumin LC–ESI–MS/MS |
| Zdroj: | South African Journal of Botany. 94:249-254 |
| ISSN: | 0254-6299 |
| DOI: | 10.1016/j.sajb.2014.07.001 |
| Popis: | In the present study, we identified the chemical constituents of 70% hydroalcoholic fraction of Picrorhiza kurroa by LC–ESI–MS/MS which showed the presence of iridoid glucosides such as picroside I, picroside II, picroside III, picroside IV, kutkoside, pikuroside and flavonoids like apocynin and vanillic acid. P. kurroa exhibited DPPH radical scavenging and metal chelating activities with IC50 of 75.16 ± 3.2 and 55.5 ± 4.8 μg/mL and also showed potent reducing power and total antioxidant activities. The extract inhibited macromolecule damage such as H2O2 induced plasmid DNA damage and AAPH induced oxidation of bovine serum albumin and lipid peroxidation of rat hepatic tissues. |
| Databáze: | OpenAIRE |
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