A microRNA‐clinical prognosis model to predict the overall survival for kidney renal clear cell carcinoma
| Autor: | Zhan Yang, Jianjian Zheng, Chunxue Li, Xuantong Xu, Rongrong Zhang, Yating Zhan, Kai Zhu, Guo Yong |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Oncology Cancer Research Multivariate statistics medicine.medical_specialty Bioinformatics Biology Metastasis nomogram Internal medicine microRNA medicine Humans Radiology Nuclear Medicine and imaging KEGG Carcinoma Renal Cell Gene Research Articles RC254-282 kidney renal clear cell carcinoma Framingham Risk Score Proportional hazards model Neoplasms. Tumors. Oncology. Including cancer and carcinogens Middle Aged Nomogram Prognosis medicine.disease Survival Analysis Kidney Neoplasms prognosis model MicroRNAs Female Research Article |
| Zdroj: | Cancer Medicine, Vol 10, Iss 17, Pp 6128-6139 (2021) Cancer Medicine |
| ISSN: | 2045-7634 |
| Popis: | Numerous studies have shown that microRNA (miRNA) serves as key regulatory factors in the origin and development of cancers. However, the biological mechanisms of miRNAs in kidney renal clear cell carcinoma (KIRC) are still unknown. It is necessary to construct an effective miRNA‐clinical model to predict the prognosis of KIRC. In this study, 94 differentially expressed miRNAs were found between para‐tumor and tumor tissues based on the Cancer Genome Atlas (TCGA) database. Seven miRNAs (hsa‐miR‐21‐5p, hsa‐miR‐3613‐5p, hsa‐miR‐144‐5p, hsa‐miR‐376a‐5p, hsa‐miR‐5588‐3p, hsa‐miR‐1269a, and hsa‐miR‐137‐3p) were selected as prognostic indicators. According to their cox coefficient, a risk score formula was constructed. Patients with risk scores were divided into high‐ and low‐risk groups based on the median score. Kaplan–Meier curves analysis showed that the low‐risk group had a better survival probability compared to the high‐risk group. The area under the ROC curve (AUC) value of the miRNA model was 0.744. In comparison with clinical features, the miRNA model risk score was considered as an independent prognosis factor in multivariate Cox regression analysis. In addition, we built a nomogram including age, metastasis, and miRNA prognostic model based on the results of multivariate Cox regression analysis. The decision curve analysis (DCA) revealed the clinical net benefit of the prognostic model. Gene set enrichment analysis (GSEA) results suggested that several important pathways may be the potential pathways for KIRC. The results of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis for the target genes of 7 miRNAs revealed that miRNAs may participate in KIRC progression via many specific pathways. Additionally, the levels of seven prognostic miRNAs showed a significant difference between KIRC tissues and adjacent non‐tumorous tissues. In conclusion, the miRNA‐clinical model provides an effective and accurate way to predict the prognosis of KIRC. In this study, we constructed a novel 7‐miRNA risk model for KIRC, which may be an independent predictor for KIRC. Moreover, a nomogram including the above risk model and clinical features could provide a better way to evaluate the prognosis of KIRC patients. |
| Databáze: | OpenAIRE |
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