Antibiotics administration during last trimester of pregnancy is associated with atopic dermatitis – a cross-sectional study
| Autor: | Gabriel Pop, Adina Mihaela Epure, Larisa Georgiana Simon, Andrei Pop, Brigitta Ana Giuca, Mihaela Panduru, Brindusa Cimpoca, Cristina Nicoleta Cozma, Mircea Robu, Nicolae Mircea Panduru |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Cross-sectional study medicine.drug_class Pregnancy Trimester Third atopic eczema Antibiotics Context (language use) 030204 cardiovascular system & hematology Logistic regression 3rd trimester antibiotics Dermatitis Atopic 03 medical and health sciences 0302 clinical medicine Pregnancy Risk Factors Internal medicine Humans Medicine antibiotherapy 030212 general & internal medicine Pregnancy Complications Infectious Child atopic dermatitis business.industry Atopic dermatitis medicine.disease RC31-1245 Rheumatology Anti-Bacterial Agents Pregnancy Trimester First Cross-Sectional Studies Logistic Models Child Preschool Pregnancy Trimester Second Prenatal Exposure Delayed Effects Female business |
| Zdroj: | Romanian Journal of Internal Medicine, Vol 58, Iss 2, Pp 99-107 (2020) |
| ISSN: | 2501-062X |
| DOI: | 10.2478/rjim-2020-0006 |
| Popis: | Introduction. Studies regarding antibiotics administration during pregnancy and atopic dermatitis (AD) in children are only few. In this context, the objective of our study was to investigate the potential association between the timing of intrauterine exposure to antibiotics or prenatal antibiotic administration in general and AD occurrence in children. Methods. This was a cross-sectional study in 1046 subjects. The exposure to antibiotics during pregnancy was initially evaluated using simple logistic regressions. Then, each period of antibiotics administration was adjusted with the other periods of antibiotics exposure (model 1) and with the other variables associated with AD in our database (model 2). Results. In simple logistic regression analysis, the administration of antibiotics during pregnancy, as a whole period, presented a trend of association with AD (OR = 1.28, %CI: 0.99 – 1.65). When we analyzed antibiotic administration during each trimester of pregnancy, only antibiotherapy during the 3rd trimester was associated with AD (OR = 2.94, %CI: 1.21 – 7.12). After adjusting with all the other important risk factors associated with AD in the database, antibiotics administration during the 3rd trimester of pregnancy was still independently associated with AD (OR=2.64, %CI: 1.01 – 6.91). Conclusion. Antibiotic administration during the 3rd trimester of pregnancy was independently associated with AD in children. |
| Databáze: | OpenAIRE |
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