Isolation and study of fosfomycin-resistant mutants of group A and B streptococci

Autor:	L E Ravdonikas, Artem A. Totolian, K B Grabovskaya
Rok vydání:	1988
Předmět:	Mutation Mutant Streptococcus Drug Resistance Microbial General Medicine Biology Fosfomycin medicine.disease_cause Streptococcaceae biology.organism_classification Microbiology Group A chemistry.chemical_compound Biochemistry chemistry Glycerol medicine Lipoteichoic acid Bacteria medicine.drug
Zdroj:	Scopus-Elsevier
ISSN:	1874-9356 0015-5632
DOI:	10.1007/bf02925778
Popis:	Eighty-nine fosfomycin-resistant mutants of group A and B streptococci were isolated. The mutants differed essentially from the parent strains in cell-wall characteristics, such as morphology of cocci and chains, sensitivity to detergents and hydrophobic properties. At the same time, the recipient activity of the investigated mutants was not changed. It is supposed that resistance of mutants to fosfomycin is connected with a transport block of glycerol 3-phosphate--important lipoteichoic acid (LTA) structural component. Fosr mutants can be useful for experimental examination of Beachey's hypothesis about the importance of LTA or its complex with the M protein for adhesion.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e235c4c2e460013abd348f9f0b49cab0 https://doi.org/10.1007/bf02925778 Zobrazit plný text záznamu Full text from SpringerLink