Associations of coffee consumption with markers of liver injury in the insulin resistance atherosclerosis study

Autor: J. K. Stiles, Carlos Lorenzo, Lynne E. Wagenknecht, S. J. Hamren, S. M. Haffner, Steven M. Watkins, J. C. Dickson, Angela D. Liese, Anthony J. Hanley
Rok vydání: 2015
Předmět:
Male
alpha-2-HS-Glycoprotein
ALT
Type 2 diabetes
Coffee
chemistry.chemical_compound
0302 clinical medicine
Insulin resistance atherosclerosis study
Liver Function Tests
Non-alcoholic Fatty Liver Disease
Surveys and Questionnaires
030212 general & internal medicine
2. Zero hunger
Liver injury
medicine.diagnostic_test
Fatty liver
Gastroenterology
Alanine Transaminase
General Medicine
Middle Aged
Liver enzymes
3. Good health
Liver
Decaffeinated
Female
Caffeine
Research Article
medicine.medical_specialty
030209 endocrinology & metabolism
digestive system
03 medical and health sciences
Insulin resistance
Diabetes mellitus
Internal medicine
medicine
Humans
Aspartate Aminotransferases
AST
business.industry
Hepatology
Protective Factors
medicine.disease
digestive system diseases
Fetuin-A
Endocrinology
chemistry
Diabetes Mellitus
Type 2
Linear Models
NAFLD liver fat score
Insulin Resistance
Liver function tests
business
Biomarkers
Zdroj: BMC Gastroenterology
ISSN: 1471-230X
Popis: Background Coffee consumption has been associated with reduced risk of developing type 2 diabetes mellitus (T2DM) however, the mechanism for this association has yet to be elucidated. Non-alcoholic fatty liver disease (NAFLD) characterizes and predicts T2DM yet the relationship of coffee with this disorder remains unclear. Our aim was to investigate the associations of coffee with markers of liver injury in 1005 multi-ethnic, non-diabetic adults in the Insulin Resistance Atherosclerosis Study. Methods Dietary intake was assessed using a validated 114-item food frequency questionnaire. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and fetuin-A were determined in fasting blood samples and the validated NAFLD liver fat score was calculated. Multivariate linear regression assessed the contribution of coffee to variation in markers of liver injury. Results Caffeinated coffee showed significant inverse associations with ALT (β = −0.08, p = 0.0111), AST (β = −0.05, p = 0.0155) and NAFLD liver fat score (β = −0.05, p = 0.0293) but not with fetuin-A (β = 0.04, p = 0.17). When the highest alcohol consumers were excluded, these associations remained (ALT β = −0.11, p = 0.0037; AST β = −0.05, p = 0.0330; NAFLD liver fat score β = −0.06, p = 0.0298). With additional adjustment for insulin sensitivity, the relationship with ALT remained significant (ALT β = −0.08, p = 0.0400; AST β = −0.03, p = 0.20; NAFLD liver fat score β = −0.03, p = 0.27). There were no significant associations of decaffeinated coffee with liver markers. Conclusions These analyses indicate a beneficial impact of caffeinated coffee on liver morphology and/or function, and suggest that this relationship may mediate the well-established inverse association of coffee with risk of T2DM. Electronic supplementary material The online version of this article (doi:10.1186/s12876-015-0321-3) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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