Glucose Metabolism in Abdominally Obese Hypertensive and Normotensive Subjects
| Autor: | Raymond G. Hoffmann, Thomas J. Myers, Irene M. O’Shaughnessy, Brent M. Egan, Konrad T. Stepniakowski, Thomas M. Kelly, Pietro Nazzaro, Ahmed H. Kissebah |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty medicine.medical_treatment Radioimmunoassay Hemodynamics Blood Pressure Calorimetry Carbohydrate metabolism Insulin resistance Internal medicine Abdomen Internal Medicine medicine Humans Insulin Obesity Abdominal obesity Analysis of Variance Leg business.industry Metabolism Middle Aged Glucose clamp technique medicine.disease Plethysmography Forearm Glucose Endocrinology Regional Blood Flow Hypertension Glucose Clamp Technique Female Vascular Resistance medicine.symptom business Perfusion |
| Zdroj: | Hypertension. 26:186-192 |
| ISSN: | 1524-4563 0194-911X |
| DOI: | 10.1161/01.hyp.26.1.186 |
| Popis: | Abstract To determine whether the combination of obesity and hypertension results in additive defects in oxidative and nonoxidative glucose metabolism and the association of these changes with altered hemodynamic actions of insulin, we studied 11 abdominally obese hypertensive, 6 abdominally obese normotensive, and 7 lean normotensive nondiabetic subjects. Endogenous glucose production and glucose metabolized were calculated from a euglycemic clamp at 72 and 287 pmol insulin/m 2 per minute. Glucose metabolized divided by insulin was lower at 72 pmol/m 2 per minute in both obese groups than in lean normotensive subjects, at 148±14, 144±33, and 373±69 (μmol/m 2 per minute)/(pmol/L), respectively ( P P |
| Databáze: | OpenAIRE |
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