Antroduodenal motility recording identifies characteristic patterns in gastroparesis related to underlying etiology

Autor:	Maartje J. M. Hereijgers, Daniel Keszthelyi, Joanna W. Kruimel, Ad A. M. Masclee, José M. Conchillo
Přispěvatelé:	MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), Interne Geneeskunde, MUMC+: MA Maag Darm Lever (9), RS: NUTRIM - R2 - Liver and digestive health, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy
Rok vydání:	2022
Předmět:	Myoelectric Complex Migrating Gastroparesis INTERSTITIAL-CELLS Endocrine and Autonomic Systems Physiology DIABETICS STATEMENT SURGERY Duodenum Manometry Gastroenterology SOLIDS migrating motor complex BREATH TEST ASSOCIATION Middle Aged DIAGNOSIS CAJAL Diabetic Neuropathies Humans Female MEAL Gastrointestinal Motility antroduodenal manometry
Zdroj:	Neurogastroenterology and Motility, 34(11):e14394. Wiley
ISSN:	1365-2982 1350-1925
Popis:	Background Gastroparesis (GP) is a gastrointestinal disorder associated with significant morbidity and healthcare costs. GP patients form a heterogeneous population with diverse etiology, and treatment is often challenging due to a poorly understood underlying pathophysiology. The aim of the present study was to assess antroduodenal motility patterns among the different GP etiologies. Methods We reviewed antroduodenal manometry (ADM) recordings of patients with confirmed GP between 2009 and 2019. ADM measurements were evaluated for fed period duration, number of phase III contractions and migrating motor complexes (MMCs), motility index (MI), and presence of neuropathic patterns. Key results A total of 167 GP patients (142 women, median age 45 [31-57]) were included. The following etiologies were identified: idiopathic n = 101; post-surgery n = 36; and diabetes n = 30. Fed period duration was significantly longer in idiopathic (p < 0.01) and diabetic GP patients (p < 0.05) compared with post-surgery GP patients. Furthermore, the number and duration of phase III contractions and the number of MMCs were significantly lower in idiopathic and diabetic patients compared with post-surgery GP patients (p < 0.01). Likewise, absence of MMCs during 6-h recording was more often observed in idiopathic and diabetes GP patients compared with post-surgery GP patients (resp. p p < 0.05). Conclusions and Inferences Antroduodenal motility patterns are different among GP etiologies. A dysmotility spectrum was identified with different patterns ranging from post-surgery GP to idiopathic and diabetic GP.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e22f3248cb4bac80fd0aef80f0740a64 https://pubmed.ncbi.nlm.nih.gov/35531931 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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