Erratum to: Cardiac ischemia in patients with septic shock randomized to vasopressin or norepinephrine
| Autor: | Sangeeta Mehta, John Granton, Anthony C. Gordon, Deborah J. Cook, Stephen Lapinsky, Gary Newton, Kris Bandayrel, Anjuli Little, Chuin Siau, Dieter Ayers, Joel Singer, Terry C. K. Lee, Keith R. Walley, Michelle Storms, D. James Cooper, Cheryl L. Holmes, Paul Hebert, Jeffrey Presneill, James A. Russell, for the Vasopressin and Septic Shock Trial (VASST) Investigators |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Vasopressin Vasopressins MEDLINE Myocardial Ischemia Critical Care and Intensive Care Medicine Norepinephrine (medication) 03 medical and health sciences Electrocardiography Norepinephrine 0302 clinical medicine Double-Blind Method Troponin T medicine Humans In patient Prospective Studies Aged Cardiac ischemia Septic shock business.industry Published Erratum lcsh:Medical emergencies. Critical care. Intensive care. First aid 030208 emergency & critical care medicine lcsh:RC86-88.9 Middle Aged medicine.disease Shock Septic Anesthesia Female Erratum business Biomarkers medicine.drug |
| Zdroj: | Critical Care Critical Care, Vol 21, Iss 1, Pp 1-1 (2017) |
| DOI: | 10.14288/1.0367862 |
| Popis: | Cardiac troponins are sensitive and specific biomarkers of myocardial necrosis. We evaluated troponin, CK, and ECG abnormalities in patients with septic shock and compared the effect of vasopressin (VP) versus norepinephrine (NE) on troponin, CK, and ECGs.This was a prospective substudy of a randomized trial. Adults with septic shock randomly received, blinded, a low-dose infusion of VP (0.01 to 0.03 U/min) or NE (5 to 15 μg/min) in addition to open-label vasopressors, titrated to maintain a mean blood pressure of 65 to 75 mm Hg. Troponin I/T, CK, and CK-MB were measured, and 12-lead ECGs were recorded before study drug, and 6 hours, 2 days, and 4 days after study-drug initiation. Two physician readers, blinded to patient data and drug, independently interpreted ECGs.We enrolled 121 patients (median age, 63.9 years (interquartile range (IQR), 51.1 to 75.3), mean APACHE II 28.6 (SD 7.7)): 65 in the VP group and 56 in the NE group. At the four time points, 26%, 36%, 32%, and 21% of patients had troponin elevations, respectively. Baseline characteristics and outcomes were similar between patients with positive versus negative troponin levels. Troponin and CK levels and rates of ischemic ECG changes were similar in the VP and the NE groups. In multivariable analysis, only APACHE II was associated with 28-day mortality (OR, 1.07; 95% CI, 1.01 to 1.14; P=0.033).Troponin elevation is common in adults with septic shock. We observed no significant differences in troponin, CK, and ECGs in patients treated with vasopressin and norepinephrine. Troponin elevation was not an independent predictor of mortality.Controlled-trials.com ISRCTN94845869. |
| Databáze: | OpenAIRE |
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